In “Lost and Wanted” by Nell Freudenberg, physics prof Helen Clapp receives a phone message from beyond the grave. Her Harvard roommate, once her closest confidante, had recently died. So what’s with the message. And why have thoughts of her old friend also kindled old romantic longings? For science-minded Helen, the world is beginning to work in mysterious ways. “Freudenberger’s brilliant and compassionate novel takes on the big questions of the universe and proves, again, that she is one of America’s greatest writers.” (Andrew Sean Greer).